{"help":"Return the metadata of a dataset (package) and its resources. :param id: the id or name of the dataset :type id: string","success":true,"result":[{"id":"ea822082-a43a-4365-8670-ef1995cc19c7","name":"thermal-tolerance-and-cardiac-phenotypes","title":"Thermal tolerance and cardiac phenotypes","author":"Zhongqi Chen","author_email":"zhongqic@uidaho.edu","maintainer":"RCDS Data Repository","maintainer_email":"rcds-web@uidaho.edu","license_title":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/","notes":"\u003Cp\u003EAdaptation to local environments involves the evolution of ecologically important traits and underlying physiological processes. Here, we used low coverage whole-genome resequencing (lcWGR) on individuals to identify genome regions involved in thermal adaptation in wild redband trout Oncorhynchus mykiss gairdneri, a subspecies of rainbow trout that inhabits ecosystems ranging from cold montane forests to high elevation deserts. This study includes allele frequency-based analyses for selective sweeps among populations, followed by multiple association tests for specific sets of phenotypes measured under thermal stress (acute and chronic survival\/mortality; high or low cardiac performance groups). Depending on the groups in each set of analyses, sequencing reads covered between 43-75% of the genome at \u226515X and each analysis included millions of SNPs across the genome. In tests for selective sweeps among populations, a total of six chromosomal regions were significant. However, association tests for specific phenotypes revealed that the region on chromosome 4 was consistently the most significant and contains the cerk gene (ceramide kinase). This study provides insight into a potential genetic mechanism of local thermal adaptation and suggests cerk may be an important candidate gene. However, further validation of this cerk gene is necessary to determine if the association with cardiac performance results in a functional role to influence thermal performance when exposed to high water temperatures and hypoxic conditions.\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EData Reuse\u003C\/strong\u003E\u003Cbr \/\u003E\n\u003Cem\u003ELicense\u003C\/em\u003E\u003Cbr \/\u003E\n\u003Ca href=\u0022https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/legalcode\u0022\u003ECC0-1.0\u003C\/a\u003E\u003Cbr \/\u003E\n\u003Cem\u003ERecommended Citation\u003C\/em\u003E\u003Cbr \/\u003E\nChen, Zhongqi (2021), Thermal tolerance and cardiac phenotypes, Dryad, Dataset, \u003Ca href=\u0022https:\/\/doi.org\/10.5061\/dryad.xwdbrv1c7\u0022\u003Ehttps:\/\/doi.org\/10.5061\/dryad.xwdbrv1c7\u003C\/a\u003E\u003C\/p\u003E\n\u003Cp\u003E\u003Cstrong\u003EFunding\u003C\/strong\u003E\u003Cbr \/\u003E\nUS National Science Foundation and Idaho EPSCoR: \u003Ca href=\u0022https:\/\/www.nsf.gov\/awardsearch\/showAward?AWD_ID=1757324\u0022\u003EOIA-1757324\u003C\/a\u003E\u003Cbr \/\u003E\nBonneville Power Administration\u003C\/p\u003E\n","url":"https:\/\/data.nkn.uidaho.edu\/dataset\/thermal-tolerance-and-cardiac-phenotypes","state":"Active","log_message":"Edited by awchild.","private":true,"revision_timestamp":"Wed, 08\/16\/2023 - 15:11","metadata_created":"Thu, 03\/03\/2022 - 12:12","metadata_modified":"Wed, 08\/16\/2023 - 15:11","creator_user_id":"6cc16f2c-77c2-4d12-ac06-56bbb86b535b","type":"Dataset","resources":[{"id":"cf718d5c-d1f0-4986-a8db-556b4cd1e3e8","revision_id":"","url":"https:\/\/doi.org\/10.5061\/dryad.xwdbrv1c7","description":"","format":"html","state":"Active","revision_timestamp":"Wed, 08\/16\/2023 - 11:33","name":"Data Access via Dryad | Thermal tolerance and cardiac phenotypes","mimetype":"html","size":"","created":"Thu, 03\/03\/2022 - 12:12","resource_group_id":"89a02fc8-c98e-44bb-9d3e-2d3d0849fbca","last_modified":"Date changed Wed, 08\/16\/2023 - 11:33"}],"tags":[{"id":"3c4b7b04-c8c8-46c4-bc38-4a5ad5c6e57a","vocabulary_id":"2","name":"climate change"},{"id":"2ddf177c-15c4-4755-a442-4d656453e890","vocabulary_id":"2","name":"common garden"},{"id":"4ff8f12f-597f-460d-98ea-6650f2124e30","vocabulary_id":"2","name":"environmental change"},{"id":"9d10045c-9469-4162-99d1-4a4bf8a3c1f0","vocabulary_id":"2","name":"genomics"},{"id":"3bbad4f9-7651-4bf2-aacd-d11b259f3642","vocabulary_id":"2","name":"Oncorhynchus mykiss gairdneri"},{"id":"36a2c71f-ca58-468c-8c5d-ea3b9e8510c8","vocabulary_id":"2","name":"Redband Trout"},{"id":"99297500-7347-473e-93dd-4f300d0c2f69","vocabulary_id":"2","name":"phenotype"},{"id":"8d9639ee-5e76-43b8-941d-eaac4dddb893","vocabulary_id":"2","name":"survival"},{"id":"df18780b-824a-4fe0-994b-3f26204982db","vocabulary_id":"2","name":"SNP"},{"id":"71b91cc8-26b6-4132-bc22-85e8f6cc74da","vocabulary_id":"2","name":"allele frequency"}],"groups":[{"description":"\u003Cp\u003ESince 1889, the University of Idaho has provided motivated students with a transformative higher education experience that prepares them to solve real-world problems and achieve success in their lives and careers.\u003C\/p\u003E\n\u003Cp\u003ELearn more at \u003Ca href=\u0022https:\/\/www.uidaho.edu\u0022\u003Ehttps:\/\/www.uidaho.edu\u003C\/a\u003E\u003C\/p\u003E\n","id":"89a02fc8-c98e-44bb-9d3e-2d3d0849fbca","image_display_url":"https:\/\/data.nkn.uidaho.edu\/sites\/default\/files\/UI_Main_horizontal_4c.jpg","title":"University of Idaho","name":"group\/university-idaho"},{"description":"\u003Cp\u003EThe primary objective of Idaho EPSCoR is to stimulate research in niche areas that can become fully competitive in the disciplinary and multidisciplinary research programs of the National Science Foundation and other relevant agencies. Idaho EPSCoR provides support for sustainable increases in Research and Development capacity and advances science and engineering capabilities within the state. \u003C\/p\u003E\n\u003Cp\u003EVisit them at \u003Ca href=\u0022https:\/\/www.idahoepscor.org\u0022\u003Ehttps:\/\/www.idahoepscor.org\u003C\/a\u003E\u003C\/p\u003E\n","id":"e696b239-9ecb-412e-b032-03a75b2b9fd6","image_display_url":"https:\/\/data.nkn.uidaho.edu\/sites\/default\/files\/Idaho_epscor_logo_no_white_background.png","title":"Idaho EPSCoR","name":"group\/idaho-epscor"},{"description":"\u003Cp\u003EGEM3 is an NSF EPSCoR research program seeking to understand how genetic diversity and phenotypic plasticity affect species response to environmental change, shaping both population response and adaptive capacity.\u003C\/p\u003E\n\u003Cp\u003EVisit them at: \u003Ca href=\u0022https:\/\/www.idahogem3.org\u0022\u003Ehttps:\/\/www.idahogem3.org\u003C\/a\u003E\u003C\/p\u003E\n","id":"1812a312-11a4-492d-960b-9a78b4abfe0c","image_display_url":"https:\/\/data.nkn.uidaho.edu\/sites\/default\/files\/GEM3_nov5_logo.png","title":"EPSCoR GEM3","name":"group\/epscor-gem3"}]}]} Error | RCDS Data Repository

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